In 2006, Košmrlj obtained Diploma (B. Sc.) in Mathematical Physics from the University of Ljubljana, Slovenia. He then moved to the Massachusetts Institute of Technology for his graduate studies in physics, where he was co-advised by Arup Chakraborty and Mehran Kardar. For his Ph.D. thesis, Košmrlj studied the development of an adaptive immune system and its response to infecting microorganisms. After receiving Ph.D. in 2011, Košmrlj became a postdoc with David Nelson at Harvard University, where he worked on the mechanics of thin membranes and metamaterials.
In 2015 Košmrlj became an assistant professor at Princeton University, where he continues theoretical and computational research of complex systems ranging from materials science to the physics of living systems. Current research includes the design and mechanics of metamaterials, where the geometrical shape of structures gives rise to unusual material properties. This includes the role of geometry and topology on the mechanics of structures both at the macro-scale and at the micro-scale, where effects of thermal fluctuations and disorder could be important if one wants to design flexible electronics, sensitive force sensors, or micro-actuators. Current research also investigates the role of mechanics in biological systems, such as mechanics in morphogenesis during embryo development. Based on this work, we are currently designing an optogenetic system to make artificial organs. Current research also includes phase separation in multicomponent systems, which has implications for materials science as well as cellular biology.
S. Mao, M. Chakraverti-Wuerthwein, H. Gaudio, and A. Košmrlj, Designing the Morphology of Separated Phases in Multicomponent Liquid Mixtures, PRL 125, 218003 (2020) https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.125.218003
S. Mao, D. Kuldinow, M. P. Haataja, and A. Košmrlj, Phase behavior and morphology of multicomponent liquid mixtures, Soft Matter 15, 1297-1311 (2019) https://pubs.rsc.org/en/content/articlelanding/2019/SM/C8SM02045K
C. Fei, S. Mao, J. Yan, R. Alert, H.A. Stone, B.L. Bassler, N.S. Wingreen, and A. Košmrlj, Nonuniform growth and surface friction determine bacterial biofilm morphology on soft substrates, PNAS 117 (14), 7622-7632 (2020) https://doi.org/10.1073/pnas.1919607117
K. Goodwin, S. Mao, T. Guyomar, E. Miller, D. C. Radisky, A. Košmrlj, and C. M. Nelson, Smooth muscle differentiation shapes domain branches during mouse lung development, Development 146, dev181172 (2019) https://journals.biologists.com/dev/article/146/22/dev181172/223143/Smo…
A. Košmrlj, and D. R. Nelson, "Statistical Mechanics of Thin Spherical Shells", Physical Review X 7, 011002 (2017) https://journals.aps.org/prx/abstract/10.1103/PhysRevX.7.011002
A. Singh, A. Košmrlj, and R. Bruinsma, Finite Temperature Phase Behavior of Viral Capsids as Oriented Particle Shells, PRL 124, 158101 (2020) https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.124.158101
S. Sarkar, M. Čebron, M. Brojan, and A. Košmrlj, Elastic multipole method for describing deformation of infinite two-dimensional solids with circular inclusions, PRE 103, 053003 (2021) https://journals.aps.org/pre/abstract/10.1103/PhysRevE.103.053003
S. Nagashima, H.D. Ha, D.H. Kim, A. Košmrlj, H.A. Stone, and M.-W. Moon, "Spontaneous formation of aligned DNA nanowires by capillarity-induced skin folding", Proceedings of the National Academy of Sciences of the United States of America 114, 6233-6237 (2017) https://www.pnas.org/content/114/24/6233